SARMs stand for Selective Androgen Receptor Modulators. There are Androgen receptors in body tissues to which androgens such as testosterone bind. Both Anabolic Steroids and SARMs mimic androgens and bind to these receptors. However, there is a fundamental difference because SARMs selectively target tissues, unlike anabolic steroids. Thus, sarms definition is that it acts like anabolic steroids but does not cause side effects like anabolic steroids due to their selective nature.
Mechanism of action
The question that arises is what sarms do? The answer is simple. Selective Androgen Receptor Modulators bind with the androgen receptors in muscles and bones, thereby causing the tissues of muscles and bones to grow. Since it does not affect other tissues such as the liver, prostate, skin, heart, etc., there are no side effects. On the other hand, anabolic steroids are not selective. That can give many side effects, such as hypogonadism in men and male secondary sexual characteristics in women.
Bodybuilders are using SARMs to increase muscle mass and enhance bone density. Reducing body fat without side effects is another beneficial effect of sarms. SARMs are also being researched for treating muscle wasting and osteoporosis due to their muscle and bone-building effects. SARMs are also being assessed for possible treatment of heart failure, cancer, chronic obstructive pulmonary disease, end-stage renal disease and end-stage liver disease.
The ratio of sarm for anabolic to androgenic is 10:1. Thus, it does not carry the risk of severe side effects, unlike anabolic steroids. SARMs do not adversely affect blood pressure and are not harmful to the liver. However, specific mild side effects such as nausea and low hormone levels can manifest.
There are many kinds of SARMs. Some of them have been discussed here.
Bodybuilders and athletes are using S-4 Andarine to increase lean muscle mass, lose fat and improve strength. Drug researchers are also working upon it to develop it into a drug for treating prostate diseases. A side effect of Andarine is the appearance of a yellow tint over the eyes. It can develop after using Andarine for a couple of weeks.
RAD 140 Testolone is used for anabolic hormones such as testosterone replacement therapy. It is used to improve bone health and strength and increase lean muscle mass. The anabolic to androgenic ratio is a massive 90:1, which means the users can build muscles and derive other benefits without any androgenic side effects. Suppression of testosterone is a side effect associated with RAD 140 Testolone.
LGD 4033 is a bulking agent which makes it suitable for bodybuilders. It is also being considered for helping in the development of the immune and reproductive systems. The high estrogen effect is associated with LGD4033, so it is better to use an anti-estrogen supplement.
MK2866 Ostarine-Ostabolic is used to build lean muscle mass, improve strength, and accelerate the healing process of joints. It is also clinically evaluated for treating muscle wasting disease and improving bone health. Suppression of natural production of testosterone is seen in longer cycles featuring high doses. Thus, SERM post cycle therapy is required.
MK677 Nutrobal increases the secretion of Growth Hormone in the body and also promotes the release of IGF-1. It helps in losing excess body fat and increases lean muscle mass. Thus PCT is not required. The recommended period for a cycle of MK677 is three months, with the dose increasing every month.
GD4033 Anabolicum increases lean muscle mass which is why athletes prefer it. In addition, it is also beneficial for joints, soft tissues and bones. Clinical trials of this sarm are taking place to evaluate its effectiveness in treating muscle wasting.
Sale and legality
Even though clinical trials have shown that SARMs are well tolerated, there are concerns about toxicity and other side effects by agencies such as US FDA. Thus, SARMs have not received regulatory approval and have not been allowed for human consumption. Many online pharmacies offer selective androgen receptor modulators for sale, but they are sold as research chemicals not approved for consumption.
SARMs have become very popular among bodybuilders despite a lack of regulatory approval. World Anti-Doping Agency prohibits SARMs. Thus athletes participating in national or international competitions should not use SARMs because a dope test would detect SARMs in the system, resulting in rejection from the competition. However, if you are not competing in any sporting event, SARMs purchased from a legal pharmacy can be consumed in consultation with a medical expert.